Endocrine Abstracts

Theca cells are indispensable for female reproduction being the source of androgens required for follicular oestrogen synthesis and also for interacting with androgen receptors in the ovary and other somatic tissues. Differentiated theca interna cells acquire responsiveness to LH and other endocrine signals, including insulin, that upregulate the steroidogenic pathway leading to androgen biosynthesis. In addition, numerous intraovarian factors of thecal, granulosal and/or oocy...